Wissenschaftliche Literatur zur Misteltherapie bei Krebs

Hier die gesamte zitierte wissenschaftliche Literatur in alphabetischer Reihenfolge im Überblick: 

 

Adler SR and JR Fosket: Disclosing complementary and alternative medicine use in the medical encounter: a qualitative study in women with breast cancer. J Fam Pract. 1999; 48: 453-458 http://www.ncbi.nlm.nih.gov/pubmed/10386489.

Albarrán Weick M (1998). Retrospektive Fall-Kontroll-Studie zum Stellenwert der adjuvanten Therapie des malignen Melanoms mit Iscador P.c.Hg, Dissertation, Albert-Ludwigs-Universität Freiburg (Breisgau): 100.

Antony S, R Kuttan and G Kuttan: Effect of viscum album in the inhibition of lung metastasis in mice induced by B16F10 melanoma cells. J Exp Clin Cancer Res. 1997; 16: 159-162 http://www.ncbi.nlm.nih.gov/pubmed/9261741.

Antony S, R Kuttan and G Kuttan: Inhibition of lung metastasis by adoptive immunotherapy using Iscador. Immunol Invest. 1999; 28: 1-8 http://www.ncbi.nlm.nih.gov/pubmed/10073677.

Antony S, R Kuttan and G Kuttan: Role of natural killer cells in iscador mediated inhibition of metastasis by adoptive immunotherapy. Immunol Invest. 2000; 29: 219-231 http://www.ncbi.nlm.nih.gov/pubmed/10933606.

Auerbach L, V Dostal, I Vaclavik-Fleck, E Kubista, A Rosenberger, S Rieger, W Tröger and JM Schierholz (2005). Signifikant höherer Anteil aktivierter NKZellen durch additive Misteltherapie bei chemotherapierten Mamma-Ca-Patientinnen in einer prospektiv-randomisierten doppelblinden Studie [Significant Higher Level of Activated NK-Cells in Patients with Breast Cancer Receiving Viscurn alburn Extract] during Chemotherapy. Fortschritte in der Misteltherapie. Aktueller Stand der Forschung und klinische Anwendung. Essen, Scheer R, Bauer R, Becker H, Fintelmann V, Kemper F, Schilcher, H. : 543-554.

Augustin M, PR Bock, J Hanisch, M Karasmann and B Schneider: Safety and efficacy of the long-term adjuvant treatment of primary intermediate- to high-risk malignant melanoma (UICC/AJCC stage II and III) with a standardized fermented European mistletoe (Viscum album L.) extract. Results from a multicenter, comparative, epidemiological cohort study in Germany and Switzerland. Arzneimittelforschung. 2005; 55: 38-49 http://www.ncbi.nlm.nih.gov/pubmed/15727163.

Axtner J, M Steele, M Kröz, G Spahn, H Matthes and F Schad: Health services research of integrative oncology in palliative care of patients with advanced pancreatic cancer. BMC Cancer. 2016; 16: 579 http://www.ncbi.nlm.nih.gov/pubmed/27485618.

Bar-Sela G: White-Berry Mistletoe (Viscum album L.) as complementary treatment in cancer: Does it help? European Journal of Integrative Medicine. 2011; 3: e55-e62 https://www.sciencedirect.com/science/article/abs/pii/S1876382011000242.

Bar-Sela G, M Wollner, L Hammer, A Agbarya, E Dudnik and N Haim: Mistletoe as complementary treatment in patients with advanced non-small-cell lung cancer treated with carboplatin-based combinations: a randomised phase II study. Eur J Cancer. 2013; 49: 1058-1064 http://www.ncbi.nlm.nih.gov/pubmed/23218588.

Bauer C, T Oppel, F Rueff and B Przybilla: Anaphylaxis to viscotoxins of mistletoe (Viscum album) extracts. Ann Allergy Asthma Immunol. 2005; 94: 86-89 http://www.ncbi.nlm.nih.gov/pubmed/15702822.

Becker H and JM Scher (2005). Kurzer Überblick über die Inhaltsstoffe der Mistel (Viscum album L.). Fortschritte in der Misteltherapie. R. Scheer, R. Bauer, H. Becker et al. Essen, KVC Verlag: 3-11.

Beuth J, B Schneider and JM Schierholz: Impact of complementary treatment of breast cancer patients with standardized mistletoe extract during aftercare: a controlled multicenter comparative epidemiological cohort study. Anticancer Res. 2008; 28: 523-527 https://www.ncbi.nlm.nih.gov/pubmed/18383896.

Bock PR, WE Friedel, J Hanisch, M Karasmann and B Schneider: [Efficacy and safety of long-term complementary treatment with standardized European mistletoe extract (Viscum album L.) in addition to the conventional adjuvant oncologic therapy in patients with primary non-metastasized mammary carcinoma. Results of a multi-center, comparative, epidemiological cohort study in Germany and Switzerland]. Arzneimittelforschung. 2004; 54: 456-466 http://www.ncbi.nlm.nih.gov/pubmed/15460213.

Bock PR, J Hanisch, H Matthes and KS Zanker: Targeting inflammation in cancer-related-fatigue: a rationale for mistletoe therapy as supportive care in colorectal cancer patients. Inflamm Allergy Drug Targets. 2014; 13: 105-111 http://www.ncbi.nlm.nih.gov/pubmed/24766319.

Boie D (1977). Die zusätzliche Helixor-Therapie beim Prostata-Karzinom des Stadium D. Arbeitsbericht. Rosenfeld, Verein für Leukämie- und Krebs-Therapie.

Bouzek T. Misteltherapie bei Patienten mit Hirntumoren: 3 Kasuistiken. Der Merkurstab. Zeitschrift für Anthroposophische Medizin 2012;65(3):249-256. DOI: https://doi.org/10.14271/DMS-19966-DE

Braedel-Ruoff S: Immunomodulatory effects of Viscum album extracts on natural killer cells: review of clinical trials. Forsch Komplementmed. 2010; 17: 63-73 http://www.ncbi.nlm.nih.gov/pubmed/20484913.

Brandenburger M, AP Simoes-Wüst, M Rostock, L Rist and R Saller (2013). Quality-of-life of cancer patients during mistletoe therapy - An exploratory stdy with the additional use of questionnaires (Lebensqualität von Krebspatienten während der Misteltherapie - Eine explorative Studie mit dem zusätzlichen Einsatz von Fragebögen). Die Mistel in der Tumortherapie 3, Aktueller Stand der Forschung und klinische Anwendung. R. Scheer, S. Alban, H. Becker et al. Essen, KVC Verlag.

Burger AM, U Mengs, G Kelter, JB Schuler and HH Fiebig: No evidence of stimulation of human tumor cell proliferation by a standardized aqueous mistletoe extract in vitro. Anticancer Res. 2003; 23: 3801-3806 http://www.ncbi.nlm.nih.gov/pubmed/14666680.

Burkhart J, C Walchli, P Heusser, U Weissenstein, S Baumgartner and AC Andres: In vitro investigation into the potential of a mistletoe extract to alleviate adverse effects of cyclophosphamide. Altern Ther Health Med. 2010; 16: 40-48 http://www.ncbi.nlm.nih.gov/pubmed/20486623.

Büssing A. Mistletoe. The Genus Viscum. Amsterdam, the Netherlands: Hardwood Academic Publishers; 2000.

Büssing A (2001). Viscum album L. – Mechanismen der Zytotoxizität. . Die Mistel in der Tumortherapie. R. Scheer , R. Bauer, H. Becker, A. P. Berg and V. Fintelmann. Essen, KCV Verlag: 121-134.

Büssing A, T Azhari, H Ostendorp, A Lehnert and K Schweizer: Viscum album L. extracts reduce sister chromatid exchanges in cultured peripheral blood mononuclear cells. Eur J Cancer. 1994; 30A: 1836-1841 http://www.ncbi.nlm.nih.gov/pubmed/7880615.

Büssing A, M Bischof, W Hatzmann, F Bartsch, D Soto-Vera, EM Fronk, M Gmeindl and GM Stein: Prevention of surgery-induced suppression of granulocyte function by intravenous application of a fermented extract from Viscum album L. in breast cancer patients. Anticancer Res. 2005; 25: 4753-4757 http://www.ncbi.nlm.nih.gov/pubmed/16334172.

Büssing A, M Girke, C Heckmann, F Schad, T Ostermann and M Kröz: Validation of the self-regulation questionnaire as a measure of health in quality of life research. Eur J Med Res. 2009; 14: 223-227 https://www.ncbi.nlm.nih.gov/pubmed/19541580.

Büssing A, H Jungmann, K Suzart and K Schweizer: Suppression of sister chromatid exchange-inducing DNA lesions in cultured peripheral blood mononuclear cells by Viscum album L. Journal of Experimental and Clinical Cancer Research. 1996; 15: 199-205.

Büssing A, C Raak and T Ostermann: Quality of life and related dimensions in cancer patients treated with mistletoe extract (iscador): a meta-analysis. Evid Based Complement Alternat Med. 2012; 2012: 219402 http://www.ncbi.nlm.nih.gov/pubmed/21747894.

Büssing A, A Regnery and K Schweizer: Effects of Viscum album L. on cyclophosphamide-treated peripheral blood mononuclear cells in vitro: sister chromatid exchanges and activation/proliferation marker expression. Cancer Lett. 1995; 94: 199-205 http://www.ncbi.nlm.nih.gov/pubmed/7634248.

Büssing A, G Schaller and U Pfüller: Generation of reactive oxygen intermediates (ROI) by the thionins from Viscum album L. Anticancer Res. 1998; 18: 4291-4296 http://www.ncbi.nlm.nih.gov/pubmed/9891480.

Büssing A, D Schietzel, M Schink and GM Stein (2005). Keine Stimulation in vitro kultivierter Tumorzellen durch Mistellektine. Fortschritte in der Misteltherapie. R. Scheer, R. Bauer, H. Becker et al. Essen, KVC Verlag: 281-290.

Büssing A and M Schietzel: Apoptosis-inducing properties of Viscum album L. extracts from different host trees, correlate with their content of toxic mistletoe lectins. Anticancer Res. 1999; 19: 23-28 http://www.ncbi.nlm.nih.gov/pubmed/10226520.

Büssing A, K Suzart, J Bergmann, U Pfüller, M Schietzel and K Schweizer: Induction of apoptosis in human lymphocytes treated with Viscum album L. is mediated by the mistletoe lectins. Cancer Lett. 1996; 99: 59-72 http://www.ncbi.nlm.nih.gov/pubmed/8564930.

Büssing A, W Vervecken, M Wagner, B Wagner, U Pfüller and M Schietzel: Expression of mitochondrial Apo2.7 molecules and caspase-3 activation in human lymphocytes treated with the ribosome-inhibiting mistletoe lectins and the cell membrane permeabilizing viscotoxins. Cytometry. 1999; 37: 133-139 http://www.ncbi.nlm.nih.gov/pubmed/10486525.

Chen DS and I Mellman: Oncology meets immunology: the cancer-immunity cycle. Immunity. 2013; 39: 1-10 http://www.ncbi.nlm.nih.gov/pubmed/23890059.

Cramer H, L Cohen, G Dobos and CM Witt: Integrative oncology: best of both worlds-theoretical, practical, and research issues. Evid Based Complement Alternat Med. 2013; 2013: 383142 http://www.ncbi.nlm.nih.gov/pubmed/24371456.

Debreczeni JE, B Girmann, A Zeeck, R Kratzner and GM Sheldrick: Structure of viscotoxin A3: disulfide location from weak SAD data. Acta Crystallogr D Biol Crystallogr. 2003; 59: 2125-2132 http://www.ncbi.nlm.nih.gov/pubmed/14646070.

DiGianni LM, JE Garber and EP Winer: Complementary and alternative medicine use among women with breast cancer. J Clin Oncol. 2002; 20: 34S-38S http://www.ncbi.nlm.nih.gov/pubmed/12235222.

Drozdoff L, E Klein, M Kiechle and D Paepke: Use of biologically-based complementary medicine in breast and gynecological cancer patients during systemic therapy. BMC Complement Altern Med. 2018; 18: 259 http://www.ncbi.nlm.nih.gov/pubmed/30249217.

Eggermont A, UR Kleeberg, DJ Ruiter and S Suciu (2001). European Organization for Research and Treatment of Cancer Melanoma Group trial experience with more than 2,000 patients, evaluating adjuvant treatment with low or intermediate dose of interferon alpha-2b. American Society of Clinical Oncology Educational Book. A. S. o. c. Oncology. Baltimore, MD, Lippincott Williams & Wilkins.

Eisenbraun J (2016). Intravesikaler Mistelextract bei Patienten mit nicht-muskelinvasivem Harnblasenkarzinom: Eine Phase III-Wirksamkeitsstudie - Aktueller Stand. Die Mistel in der Tumortherapie 4. Aktueller Stand der Forschung und klinische Anwendung. R. Scheer, S. Alban, H. Becker et al. Essen, KVC Verlag: 345-354.

Eisenbraun J (2016). Mistelextrakt bei Patienten mit nichtmuskelinvasivem Harnblasenkarzinom - Ergebnisse einer einarmigen Phase Ib/IIa Dosiseskalationsstudie. Die Mistel in der Tumortherapie 4. Aktueller Stand der Forschung und klinische Anwendung. R. Scheer, S. Alban, H. Becker et al. Essen, KVC Verlag: 331-334.

Eisenbraun J, R Scheer, M Kröz, F Schad and R Huber: Quality of life in breast cancer patients during chemotherapy and concurrent therapy with a mistletoe extract. Phytomedicine. 2011; 18: 151-157 http://www.ncbi.nlm.nih.gov/pubmed/20724129.

Elluru S, JP Duong Van Huyen, S Delignat, F Prost, J Bayry, MD Kazatchkine and SV Kaveri: Molecular mechanisms underlying the immunomodulatory effects of mistletoe (Viscum album L.) extracts Iscador. Arzneimittelforschung. 2006; 56: 461-466 http://www.ncbi.nlm.nih.gov/pubmed/16927527.

Elluru S, JPD Huyen van, B Wootla, S Delignat, F Prost, VS Negi and SV Kaveri: Tumor regressive effects of Viscum album preparations – Exploration of immunomodulatory mechanisms. Medicina. 2007; 67: 85-89.

Elluru SR, JP Duong van Huyen, S Delignat, MD Kazatchkine, A Friboulet, SV Kaveri and J Bayry: Induction of maturation and activation of human dendritic cells: a mechanism underlying the beneficial effect of Viscum album as complimentary therapy in cancer. BMC Cancer. 2008; 8: 161 http://www.ncbi.nlm.nih.gov/pubmed/18533025.

Elsasser-Beile U, M Voss, R Schuhle and U Wetterauer: Biological effects of natural and recombinant mistletoe lectin and an aqueous mistletoe extract on human monocytes and lymphocytes in vitro. J Clin Lab Anal. 2000; 14: 255-259 http://www.ncbi.nlm.nih.gov/pubmed/11138605.

Engdal S and OG Nilsen: In vitro inhibition of CYP3A4 by herbal remedies frequently used by cancer patients. Phytother Res. 2009; 23: 906-912 http://www.ncbi.nlm.nih.gov/pubmed/19170155.

Ernst E, K Schmidt and MK Steuer-Vogt: Mistletoe for cancer? A systematic review of randomised clinical trials. Int J Cancer. 2003; 107: 262-267 http://www.ncbi.nlm.nih.gov/pubmed/12949804.

Fasching PA, F Thiel, K Nicolaisen-Murmann, C Rauh, J Engel, MP Lux, MW Beckmann and MR Bani: Association of complementary methods with quality of life and life satisfaction in patients with gynecologic and breast malignancies. Support Care Cancer. 2007; 15: 1277-1284 http://www.ncbi.nlm.nih.gov/pubmed/17333294.

Fischer A (2006). Charakterisierung der immunmodulatorischen Wirkung von Mistelpräparaten auf Zellen des Immunsystems bei Rindern. Dissertation, Universität Hannover.

Fischer S (1996). In vitro-Versuche zur T-Zellaktivität. Stuttgart, Hippokrates Verlag.

Franz H, P Ziska and A Kindt: Isolation and properties of three lectins from mistletoe (Viscum album L.). Biochem J. 1981; 195: 481-484 http://www.ncbi.nlm.nih.gov/pubmed/7316963.

Franz M (2003). Struktur und biologische Aktivitäten der chitinbindenden Mistellektine. Dissertation, University Tübingen.

Frenkel M and L Cohen: Effective communication about the use of complementary and integrative medicine in cancer care. J Altern Complement Med. 2014; 20: 12-18 http://www.ncbi.nlm.nih.gov/pubmed/23863085.

Friedel WE, H Matthes, PR Bock and KS Zanker: Systematic evaluation of the clinical effects of supportive mistletoe treatment within chemo- and/or radiotherapy protocols and long-term mistletoe application in nonmetastatic colorectal carcinoma: multicenter, controlled, observational cohort study. J Soc Integr Oncol. 2009; 7: 137-145 http://www.ncbi.nlm.nih.gov/pubmed/19883529.

Friess H, HG Beger, J Kunz, N Funk, M Schilling and MW Buchler: Treatment of advanced pancreatic cancer with mistletoe: results of a pilot trial. Anticancer Res. 1996; 16: 915-920 http://www.ncbi.nlm.nih.gov/pubmed/8687151.

Giudici M, K Villalain, K Pfüller and U Pfüller (2005). Membranaktivität der Viscotoxine A3 und B – Interaktionen mit Modellmembranen. Fortschritte in der Misteltherapie. R. Scheer, R. Bauer, H. Becker et al. Essen, KVC Verlag: 99-107.

Grah C, A Kurzeja, B Matthes, A Eichberger, A Wüstfeld, K Kunc, U Weissenstein, C Thieme, A Müssig, F Schad and M Reif (2019). Immun-Checkpoint-Inhibition plus Viscum album L.- Extrakt beim Lungenkarzinom. Conference: 60. Kongress der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin e. V.

Greenlee H, LG Balneaves, LE Carlson, M Cohen, G Deng, D Hershman, M Mumber, J Perlmutter, D Seely, A Sen, SM Zick, D Tripathy and O Society for Integrative: Clinical practice guidelines on the use of integrative therapies as supportive care in patients treated for breast cancer. J Natl Cancer Inst Monogr. 2014; 2014: 346-358 http://www.ncbi.nlm.nih.gov/pubmed/25749602.

Greenlee H, MJ DuPont-Reyes, LG Balneaves, LE Carlson, MR Cohen, G Deng, JA Johnson, M Mumber, D Seely, SM Zick, LM Boyce and D Tripathy: Clinical practice guidelines on the evidence-based use of integrative therapies during and after breast cancer treatment. CA Cancer J Clin. 2017; 67: 194-232 http://www.ncbi.nlm.nih.gov/pubmed/28436999.

Grossarth-Maticek R, H Kiene, SM Baumgartner and R Ziegler: Use of Iscador, an extract of European mistletoe (Viscum album), in cancer treatment: prospective nonrandomized and randomized matched-pair studies nested within a cohort study. Altern Ther Health Med. 2001; 7: 57-66, 68-72, 74-56 passim http://www.ncbi.nlm.nih.gov/pubmed/11347286.

Grossarth-Maticek R and R Ziegler: Prospective controlled cohort studies on long-term therapy of breast cancer patients with a mistletoe preparation (Iscador). Forsch Komplementmed. 2006; 13: 285-292 http://www.ncbi.nlm.nih.gov/pubmed/17057389.

Grossarth-Maticek R and R Ziegler: Efficacy and safety of the long-term treatment of melanoma with a mistletoe preparation (Iscador). Schweizerische Zeitschrift für GanzheitsMedizin. 2007.

Grossarth-Maticek R and R Ziegler: Prospective controlled cohort studies on long-term therapy of cervical cancer patients with a mistletoe preparation (Iscador). Forsch Komplementmed. 2007; 14: 140-147 http://www.ncbi.nlm.nih.gov/pubmed/17596694.

Grossarth-Maticek R and R Ziegler: Prospective Controlled Cohort Studies on Long-term Therapy of Ovarian Cancer Patients with Mistletoe (Viscum album L.) Extracts Iscador. Arzneimittelforschung. 2007; 57: 665-678 https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0031-1296666.

Grossarth-Maticek R and R Ziegler: Randomized and non-randomized prospective controlled cohort studies in matched pair design for the long-term therapy of corpus uteri cancer patients with a mistletoe preparation (Iscador). European Journal of Medical Research. 2008; 13: 107-120.

Gschwendtner KM, C Holmberg and J Weis: Beweggründe von Krebspatienten für und gegen die Inanspruchnahme der Misteltherapie. Forsch Komplementmed. 2016; 23: 215–222.

Gutsch J (2001). Außergewöhnlicher Krankheitsverlauf bei metastasierendem Mammakarzinom unter Misteltherapie nach pseudoallergischer Reaktion. Die Mistel in der Tumortherapie. Grundlagenforschung und Klinik. R. Scheer, R. Bauer, B. H, P. A. Berg and V. Fintelmann. Essen, KVC Verlag: 379-387.

Gutsch J, S Rieger, JM Schierholz and D Schlodder (2008). Observational study on treatment with standardized Viscum album extracts (VA-E) in lymphocytic non-Hodgkin's lymphoma (CLL) - safety and course. Die Mistel in der Tumortherapie 2, Akuteller Stand der Forschung und klinische Anwendung. R. Scheer, S. Alban, H. Becker et al. Essen, KVC Verlag.

Gutsch J, S Rieger and D Schlodder (2013). Observational study on treatment of lymphocytic non-Hodkin lymphoma (CLL) with in-process-standardized Viscum album products Helixor P or A - Clinical course and safety. Die Mistel in der Tumortherapie 3 , Aktueller Stand der Forschung und klinische Anwendung. R. Scheer, A. S, B. H et al. Essen, KVC Verlag.

Gutsch J, PG Werthmann, A Rosenwald and GS Kienle: Complete Remission and Long-term Survival of a Patient with a Diffuse Large B-cell Lymphoma Under Viscum album Extracts After Resistance to R-CHOP: A Case Report. Anticancer Res. 2018; 38: 5363-5369 http://www.ncbi.nlm.nih.gov/pubmed/30194190.

Hajto T, K Fodor, P Perjesi and P Nemeth: Difficulties and perspectives of immunomodulatory therapy with mistletoe lectins and standardized mistletoe extracts in evidence-based medicine. Evid Based Complement Alternat Med. 2011; 2011: 298972 http://www.ncbi.nlm.nih.gov/pubmed/19939951.

Hall AH, DG Spoerke and BH Rumack: Assessing mistletoe toxicity. Ann Emerg Med. 1986; 15: 1320-1323 http://www.ncbi.nlm.nih.gov/pubmed/2877602.

Heinzerling L, V von Baehr, C Liebenthal, R von Baehr and HD Volk: Immunologic effector mechanisms of a standardized mistletoe extract on the function of human monocytes and lymphocytes in vitro, ex vivo, and in vivo. J Clin Immunol. 2006; 26: 347-359 http://www.ncbi.nlm.nih.gov/pubmed/16705487.

Helyer LK, S Chin, BK Chui, B Fitzgerald, S Verma, E Rakovitch, G Dranitsaris and M Clemons: The use of complementary and alternative medicines among patients with locally advanced breast cancer--a descriptive study. BMC Cancer. 2006; 6: 39 http://www.ncbi.nlm.nih.gov/pubmed/16504038.

Hiddemann W, H Huber and C Bartram (2004). Die Onkologie. Berlin Heidelberg Springer Verlag 

Horneber M, G Bueschel, G Dennert, D Less, E Ritter and M Zwahlen: How Many Cancer Patients Use Complementary and Alternative Medicine A Systematic Review and Metaanalysis. Integrative Cancer Therapies. 2012; 11: 187-203 https://www.ncbi.nlm.nih.gov/pubmed/22019489.

Horneber MA, G Bueschel, R Huber, K Linde and M Rostock: Mistletoe therapy in oncology. Cochrane Database Syst Rev. 2008: CD003297 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18425885.

Huber R, K Classen, M Werner and R Klein: In vitro immunoreactivity towards lectin-rich or viscotoxin-rich mistletoe (Viscum album L.) extracts Iscador applied to healthy individuals. Arzneimittelforschung. 2006; 56: 447-456 http://www.ncbi.nlm.nih.gov/pubmed/16927525.

Huber R, Gründemann C. Die Wirkungen der Mistelsubstanz auf das Immunsystem und mögliche therapeutische Implikationen. Der Merkurstab. Zeitschrift für Anthroposophische Medizin 2018;71(4):265-268. DOI: https://doi.org/10.14271/DMS-20964-DE

Huber R, M Rostock, R Goedl, R Ludtke, K Urech, S Buck and R Klein: Mistletoe treatment induces GM-CSF- and IL-5 production by PBMC and increases blood granulocyte- and eosinophil counts: a placebo controlled randomized study in healthy subjects. Eur J Med Res. 2005; 10: 411-418 www.ncbi.nlm.nih.gov/pubmed/16287602.    

Huber R, M Rostock, R Goedl, R Ludtke, K Urech and R Klein: Immunologic effects of mistletoe lectins: a placebo-controlled study in healthy subjects. J Soc Integr Oncol. 2006; 4: 3-7 http://www.ncbi.nlm.nih.gov/pubmed/16737665.

Hutt N, M Kopferschmitt-Kubler, J Cabalion, A Purohit, M Alt and G Pauli: Anaphylactic reactions after therapeutic injection of mistletoe (Viscum album L.). Allergol Immunopathol (Madr). 2001; 29: 201-203

Janssen O, A Scheffler and D Kabelitz: In vitro effects of mistletoe extracts and mistletoe lectins. Cytotoxicity towards tumor cells due to the induction of programmed cell death (apoptosis). Arzneimittelforschung. 1993; 43: 1221-1227 http://www.ncbi.nlm.nih.gov/pubmed/8292069.

Kelter G and HH Fiebig: Absence of tumor growth stimulation in a panel of 26 human tumor cell lines by mistletoe (Viscum album L.) extracts Iscador in vitro. Arzneimittelforschung. 2006; 56: 435-440 http://www.ncbi.nlm.nih.gov/pubmed/16927523.Kempenich R, Willeke M, Meyer U. Das Prostatakarzinom und seine Behandlung mit Iscucin® Populi - Einführung und klinische Fälle aus der Praxis. Der Merkurstab. Zeitschrift für Anthroposophische Medizin 2009;62(3):255-261. DOI: https://doi.org/10.14271/DMS-19439-DE​​​​​​​

Khalili M, N Farokhnasab, M Mirzaei and F Ansari: Antinociceptive Effect of Oral and Intraperitoneal Administration of Alcoholic Viscum Album Fruit Extract in Male Rats. Journal of Basic and Clinical Pathophysiology. 2015; 3: 33-38 http://jbcp.shahed.ac.ir/article_166_f474370338c891f35b6f2f3bd02cbafa.pdf.

Khatun A, M Rahman, MM Rahman, H Hossain, IA Jahan and ML Nesa: Antioxidant, Antinociceptive and CNS Activities of Viscum orientale and High Sensitive Quantification of Bioactive Polyphenols by UPLC. Front Pharmacol. 2016; 7: 176 http://www.ncbi.nlm.nih.gov/pubmed/27445814.

Kiene H, HJ Hamre and G Kienle. "Final Comments on E. Ernst’s Systematic Review on Anthroposophical Medicine (1) and on Ernst’s Reply (2) to our Critique (3)." 60. Kongress der Deutsche Gesellschaft für Gynäkologie und Geburtshilfe, München. Retrieved 15.07.2019, from www.academia.edu

Kienle GS, F Berrino, A Büssing, E Portalupi, S Rosenzweig and H Kiene: Mistletoe in cancer - a systematic review on controlled clinical trials. Eur J Med Res. 2003; 8: 109-119 http://www.ncbi.nlm.nih.gov/pubmed/12730032.

Kienle GS, A Glockmann, M Schink and H Kiene: Viscum album L. extracts in breast and gynaecological cancers: a systematic review of clinical and preclinical research. J Exp Clin Cancer Res. 2009; 28: 79 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19519890.

Kienle GS, R Grugel and H Kiene: Safety of higher dosages of Viscum album L. in animals and humans--systematic review of immune changes and safety parameters. BMC Complement Altern Med. 2011; 11: 72 http://www.ncbi.nlm.nih.gov/pubmed/21871125.

Kienle GS, HJ Hamre and H Kiene: Anthroposophical medicine: a systematic review of randomised clinical trials. Wien Klin Wochenschr. 2004; 116: 407-408; author reply 408 http://www.ncbi.nlm.nih.gov/pubmed/15291296.

Kienle GS and H Kiene: Die Mistel in der Onkologie: Fakten und konzeptionelle Grundlagen. . Schattauer Verlag; Stuttgart, Germany. 2003.

Kienle GS and H Kiene (2003). Verträglichkeit, Nebenwirkungen, Überempfindlichkeitsreaktionen, Toxizität. Die Mistel in der Onkologie. Fakten und konzeptionelle Grundlagen. Stuttgart, New York, Schattauer Verlag: 591-607.

Kienle GS and H Kiene: Review article: Influence of Viscum album L (European mistletoe) extracts on quality of life in cancer patients: a systematic review of controlled clinical studies. Integr Cancer Ther. 2010; 9: 142-157 http://www.ncbi.nlm.nih.gov/pubmed/20483874.

Kienle GS, M Mussler, D Fuchs and H Kiene: Intravenous Mistletoe Treatment in Integrative Cancer Care: A Qualitative Study Exploring the Procedures, Concepts, and Observations of Expert Doctors. Evid Based Complement Alternat Med. 2016; 2016: 4628287 http://www.ncbi.nlm.nih.gov/pubmed/27239209.

Kienle GS, M Mussler, D Fuchs and H Kiene: The Subjective Dimension of Integrative Cancer Care: A Qualitative Study Exploring the Perspectives, Themes, and Observations of Experienced Doctors from the Area of Anthroposophic Medicine. Explore (NY). 2018; 14: 342-351 http://www.ncbi.nlm.nih.gov/pubmed/30181043.

Kim K-C, J-H Yook, J Eisenbraun, B-S Kim and R Huber: Quality of life, immunomodulation and safety of adjuvant mistletoe treatment in patients with gastric carcinoma–a randomized, controlled pilot study. BMC Complementary and Alternative Medicine. 2012; 12: 172 https://www.ncbi.nlm.nih.gov/pubmed/23033982.

Kleeberg UR, S Suciu, EB Brocker, DJ Ruiter, C Chartier, D Lienard, J Marsden, D Schadendorf, AM Eggermont and EMGicwtGC Society: Final results of the EORTC 18871/DKG 80-1 randomised phase III trial. Eur J Cancer. 2004; 40: 390-402 http://www.ncbi.nlm.nih.gov/pubmed/14746858.

Klein R (2005). Effekte von Mistelextrakten auf immunkompetente Zellen in vitro und in vivo und ihre mögliche Bedeutung für die Therapie von Tumorerkrankungen und andere klinische Entitäten. Fortschritte in der Misteltherapie. R. Scheer, R. Bauer, H. Becker et al. Essen, KVC Verlag: 207-221.

Klein R (2009). Effekte von Mistelextrakten auf immunkompetente Zellen in vitro und in vivo. Die Mistel in der Tumortherapie 2. R. Scheer, S. Alban, H. Becker et al. Essen, KVC Verlag: 185-193.

Klein R, K Classen, PA Berg, R Ludtke, M Werner and R Huber: In vivo-induction of antibodies to mistletoe lectin-1 and viscotoxin by exposure to aqueous mistletoe extracts: a randomised double-blinded placebo controlled phase I study in healthy individuals. Eur J Med Res. 2002; 7: 155-163 http://www.ncbi.nlm.nih.gov/pubmed/12010650.

Klein R, M Franz, R Wacker, K Classen, R Scheer, HB Von Laue, S Stoeva and W Voelter: Demonstration of antibodies to the chitin-binding mistletoe lectin (cbML) in tumor patients before and during therapy with an aqueous mistletoe extract. Eur J Med Res. 2004; 9: 316-322 http://www.ncbi.nlm.nih.gov/pubmed/15257874.

Klett CY and FA Anderer: Activation of natural killer cell cytotoxicity of human blood monocytes by a low molecular weight component from viscum album extract. Arzneimittelforschung. 1989; 39: 1580-1585 http://www.ncbi.nlm.nih.gov/pubmed/2624609.

Kovacs E, T Hajto and K Hostanska: Improvement of DNA repair in lymphocytes of breast cancer patients treated with Viscum album extract (Iscador). Eur J Cancer. 1991; 27: 1672-1676 http://www.ncbi.nlm.nih.gov/pubmed/1782081.

Kovacs E, S Link and U Toffol-Schmidt: Cytostatic and cytocidal effects of mistletoe (Viscum album L.) quercus extract Iscador. Arzneimittelforschung. 2006; 56: 467-473 http://www.ncbi.nlm.nih.gov/pubmed/16927528.

Kreis W (2009). Fortschritte bei der Strukturaufklärung von Inhaltsstoffen der Mistel. Die Mistel in der Tumortherapie 2. R. Scheer, S. Alban, H. Becker et al. Essen, KVC Verlag: 17-29.

Kröz M, A Büssing, M Reif, D Pranga, F Schad, R Zerm, H Matthes and M Girke (2016). Besteht eine Indikation für die Misteltherapie in der Behandlung von Cancer-related Fatigue und Insomnie bei Krebspatienten? –  Ein Review Die Mistel in der Tumortherapie 4. Aktueller Stand der Forschung und klinische Anwendung. Scheer R, Alban S, Becker H et al., KVC Verlag, Essen, 287-298.

Kröz M, A Büssing, HB von Laue, M Reif, G Feder, F Schad, M Girke and H Matthes: Reliability and validity of a new scale on internal coherence (ICS) of cancer patients. Health Qual Life Outcomes. 2009; 7: 59 http://www.ncbi.nlm.nih.gov/pubmed/19552807.

Kröz M, K Humbroich, D Brauer, R Zerm, M Kirchhoff, M Reif, BH von Laue, F Schad, E Nickel, L Arndt, M Debus and M Girke (2008). Validation of a new scale in internal coherence (ICS) with mistletoe therapy-sensitive questions for cancer patients. Die Mistel in der Tumortherapie 2, Aktueller Stand der Forschung und klinische Anwendung. R. Scheer, S. Alban, H. Becker et al.

Kröz M, M Reif, R Zerm, F Schad, BH von Laue, T Storch, B Brinkhaus, SN Willich and M Girke (2013). Mistletoe and chemotherapy responsiveness of different scales of oncological patients undergoing chemotherapy. Die Mistel in der Tumortherapie 3, Aktueller Stand der Forschung und klinische Anwendung. R. Scheer, S. Alban, B. H et al. Essen, KVC Verlag.

Kröz M, R Zerm, M Reif, VONL HB, F Schad, A Büssing, C Bartsch, G Feder and M Girke: Validation of the German version of the Cancer Fatigue Scale (CFS-D). Eur J Cancer Care (Engl). 2008; 17: 33-41 http://www.ncbi.nlm.nih.gov/pubmed/18181889.

Kuehn JJ: Treatment responses to Viscum album pini (Iscador P) in non-Hodgkin's lymphoma exploring a new therapeutic route. Medicina. 2007; 67: 107-114.

Kuehn JJ (2009). Viscum album L. Pini in der Behandlung des Non-Hodgkin-Lymphoms - Wirksamkeit und Risikoeinschätzung einer subkutanen Misteltherapie im Rahmen einer retrospektiven Fallkontrollstudie. Die Mistel in der Tumortherapie 2. R. Scheer, S. Alban, H. Becker et al. Essen, KVC Verlag: 353-373.

Kunz C, HR Heiligtag, A Hintze and K Urech (2013). Topische Behandlung des Basalzellkarzinoms mit Viscum album, lipophiler Extrakt 10%, Unguentum - Eine Fallserie-Studie. Die Mistel in der Tumortherapie 3. R. Scheer, S. Alban, H. Becker et al. Essen, KVC Verlag: 315-322.

Kuttan G and R Kuttan: Reduction of leukopenia in mice by "viscum album" administration during radiation and chemotherapy. Tumori. 1993; 79: 74-76 http://www.ncbi.nlm.nih.gov/pubmed/8497925.

Kuttan G, DM Vasudevan and R Kuttan: Isolation and identification of a tumour reducing component from mistletoe extract (Iscador). Cancer Lett. 1988; 41: 307-314 http://www.ncbi.nlm.nih.gov/pubmed/3409209.

Lange-Lindberg AM, M Velasco Garrido and R Busse: Mistletoe treatments for minimising side effects of anticancer chemotherapy. GMS Health Technol Assess. 2006; 2 http://www.ncbi.nlm.nih.gov/pubmed/21289969.

Lee RT, HJ Gabius and YC Lee: The sugar-combining area of the galactose-specific toxic lectin of mistletoe extends beyond the terminal sugar residue: comparison with a homologous toxic lectin, ricin. Carbohydr Res. 1994; 254: 269-276 http://www.ncbi.nlm.nih.gov/pubmed/8180989.

Loewe-Mesch A, JJ Kuehn, K Borho, U Abel, C Bauer, I Gerhard, A Schneeweiss, C Sohn, T Strowitzki and C v Hagens: [Adjuvant simultaneous mistletoe chemotherapy in breast cancer--influence on immunological parameters, quality of life and tolerability]. Forsch Komplementmed. 2008; 15: 22-30 http://www.ncbi.nlm.nih.gov/pubmed/18334811.

Longhi A, E Mariani and JJ Kuehn: A randomized study with adjuvant mistletoe versus oral Etoposide on post relapse disease-free survival in osteosarcoma patients. Eur J Integr Med. 2009; 1: 31-39.

Longhi A, M Reif, E Mariani and S Ferrari: A Randomized Study on Postrelapse Disease-Free Survival with Adjuvant Mistletoe versus Oral Etoposide in Osteosarcoma Patients. Evid Based Complement Alternat Med. 2014; 2014: 210198 http://www.ncbi.nlm.nih.gov/pubmed/24803944.

Lyman GH, H Greenlee, K Bohlke, T Bao, AM DeMichele, GE Deng, JM Fouladbakhsh, B Gil, DL Hershman, S Mansfield, DM Mussallem, KM Mustian, E Price, S Rafte and L Cohen: Integrative Therapies During and After Breast Cancer Treatment: ASCO Endorsement of the SIO Clinical Practice Guideline. J Clin Oncol. 2018; 36: 2647-2655 http://www.ncbi.nlm.nih.gov/pubmed/29889605.

Mabed M, L El-Helw and S Shamaa: Phase II study of viscum fraxini-2 in patients with advanced hepatocellular carcinoma. British Journal of Cancer. 2004; 90: 65-69 https://www.nature.com/articles/6601463.pdf.

Maldacker J: Preclinical investigations with mistletoe (Viscum album L.) extract Iscador. Arzneimittelforschung. 2006; 56: 497-507 http://www.ncbi.nlm.nih.gov/pubmed/16927531.

Mansky PJ, DB Wallerstedt, TS Sannes, J Stagl, LL Johnson, MR Blackman, JL Grem, SM Swain and BP Monahan: NCCAM/NCI Phase 1 Study of Mistletoe Extract and Gemcitabine in Patients with Advanced Solid Tumors. Evidence-Based Complementary and Alternative Medicine. 2013; 2013 https://www.ncbi.nlm.nih.gov/pubmed/24285980.

Matthes B (2005). Fremdstoff-metabolische Charakterisierung von Mistelpräparaten an der Leberzelle (HepG2). Fortschritte in der Misteltherapie. R. Scheer, R. Bauer, H. Becker et al. Essen, KVC Verlag 191-203.

Matthes H: Die Misteltherapie in der Onkologie - ein Update. Praxis Magazin. 2017; 9: 6-14.

Matthes H, WE Friedel and PR Bock (2008). Supportive care in pancreatic carcinoma patients treated with a fermented mistletoe (Viscum album L.) extracts. Die Mistel in der Tumortherapie 2 , Akuteller Stand der Forschung und klinische Anwendung. R. Scheer, S. Alban, H. Becker et al. Essen, KVC Verlag.

Matthes H, WE Friedel, PR Bock and KS Zanker: Molecular mistletoe therapy: friend or foe in established anti-tumor protocols? A multicenter, controlled, retrospective pharmaco-epidemiological study in pancreas cancer. Curr Mol Med. 2010; 10: 430-439 http://www.ncbi.nlm.nih.gov/pubmed/20455850.

Melzer J, F Iten, K Hostanska and R Saller: Efficacy and safety of mistletoe preparations (Viscum album) for patients with cancer diseases. A systematic review. Forsch Komplementmed. 2009; 16: 217-226 http://www.ncbi.nlm.nih.gov/pubmed/19729932.

Micke O, J Buntzel, K Kisters, U Schafer, P Micke and R Mucke: Complementary and alternative medicine in lung cancer patients: a neglected phenomenon? Front Radiat Ther Oncol. 2010; 42: 198-205 http://www.ncbi.nlm.nih.gov/pubmed/19955808.

Montbriand MJ: Abandoning biomedicine for alternate therapies: oncology patients' stories. Cancer Nurs. 1998; 21: 36-45 http://www.ncbi.nlm.nih.gov/pubmed/9494229.

Mueller EA and FA Anderer: A Viscum album oligosaccharide activating human natural cytotoxicity is an interferon gamma inducer. Cancer Immunol Immunother. 1990; 32: 221-227 http://www.ncbi.nlm.nih.gov/pubmed/2124513.

Mulsow K, T Enzlein, C Delebinski, S Jaeger, G Seifert and MF Melzig: Impact of Mistletoe Triterpene Acids on the Uptake of Mistletoe Lectin by Cultured Tumor Cells. PLOS One. 2016; 11: e0153825 http://www.ncbi.nlm.nih.gov/pubmed/27088729.

Münstedt K, A Entezami and U Kullmer: Onkologische Misteltherapie - zur Anwendung und Bewertung der Wirksamkeit durch Ärzte. Deutsche Medizinische Wochenschrift. 2000; 125: 1222-1226.

Nazaruk J and P Orlikowski: Phytochemical profile and therapeutic potential of Viscum album L. Nat Prod Res. 2016; 30: 373-385 http://www.ncbi.nlm.nih.gov/pubmed/25813519.

Oei SL, A Thronicke, M Kröz, C Herbstreit and F Schad: The Internal Coherence of Breast Cancer Patients Is Associated with the Decision-Making for Chemotherapy and Viscum album L. Treatment. Evid Based Complement Alternat Med. 2018; 2018: 1065271 http://www.ncbi.nlm.nih.gov/pubmed/30363769.

Oei SL, A Thronicke, M Kröz, C Herbstreit and F Schad: Supportive Effect of Viscum album L. extracts on the inner feeling of Warmth in Non-metastasized Breast Cancer Patients. European Journal of Integrative Medicine. 2017; 27: 97-104 https://www.sciencedirect.com/science/article/pii/S1876382018305870.

Orange M, MP Fonseca, A Lace, HB von Laue  and S Geider: Durable tumour responses following primary high does induction with mistletoe extracts. Two case reports. European Journal of Integrative Medicine. 2010; 2: 63-69 https://www.sciencedirect.com/science/article/abs/pii/S1876382010000272.

Orange M, A Lace, MP Fonseca, BH von Laue, S Geider and GS Kienle: Durable Regression of Primary Cutaneous B-Cell Lymphoma Following Fever-inducing Mistletoe Treatment: Two Case Reports. Glob Adv Health Med. 2012; 1: 18-25 http://www.ncbi.nlm.nih.gov/pubmed/24278797.

Ostermann T and A Büssing: Retrolective studies on the survival of cancer patients treated with mistletoe extracts: a meta-analysis. Explore (NY). 2012; 8: 277-281 http://www.ncbi.nlm.nih.gov/pubmed/22938746.

Ostermann T, C Raak and A Büssing: Survival of cancer patients treated with mistletoe extract (Iscador): a systematic literature review. BMC Cancer. 2009; 9: 451 http://www.ncbi.nlm.nih.gov/pubmed/20021637.

Pae HO, GS Oh, WG Seo, MK Shin, SG Hong, HS Lee and HT Chung: Mistletoe lectin synergizes with paclitaxel in human SK-hep1 hepatocarcinoma cells. Immunopharmacol Immunotoxicol. 2001; 23: 531-540 http://www.ncbi.nlm.nih.gov/pubmed/11792012.

Paepke D: Die Mistel in der Onkologie. Im Fokus Onkologie. 2018; 21: 64-68.

Pal A (2008). Structure determination of Viscotoxin A1, Tendamistat and Tri Peptidyl Peptidase-I. Dissertation. Göttingen, University Göttingen.

Pal A, JE Debreczeni, M Sevvana, T Gruene, B Kahle, A Zeeck and GM Sheldrick: Structures of viscotoxins A1 and B2 from European mistletoe solved using native data alone. Acta Crystallogr D Biol Crystallogr. 2008; 64: 985-992 http://www.ncbi.nlm.nih.gov/pubmed/18703848.

Pelzer F, W Tröger and DR Nat: Complementary Treatment with Mistletoe Extracts During Chemotherapy: Safety, Neutropenia, Fever, and Quality of Life Assessed in a Randomized Study. J Altern Complement Med. 2018; 24: 954-961 http://www.ncbi.nlm.nih.gov/pubmed/30247950.

Pfeifer B, J Preiß and C Unger (2006). Onkologie integrativ München, Urban & Fischer Verlag.

Pfüller U (2000). Chemical constituents of European mistletoe (Viscum album L.). Mistletoe - The Genus Viscum. A. Büssing. Amsterdam, Harwood Academic Publishers: 1-122.

Piao BK, YX Wang, GR Xie, U Mannsmann, H Matthes, J Beuth and HS Lin: Impact of complementary mistletoe extract treatment on quality of life in breast, ovarian and non-small cell lung cancer patients. A prospective randomized controlled clinical trial. Anticancer Research. 2004; 24: 303-310 http://ar.iiarjournals.org/content/24/1/303.abstract.

Pichler WJ and R Angeli: [An allergy to mistletoe extract]. Dtsch Med Wochenschr. 1991; 116: 1333-1334 http://www.ncbi.nlm.nih.gov/pubmed/1879330.

Ribereau-Gayon G, ML Jung, S Baudino, G Salle and JP Beck: Effects of mistletoe (Viscum album L.) extracts on cultured tumor cells. Experientia. 1986; 42: 594-599 http://www.ncbi.nlm.nih.gov/pubmed/3013672.

Rieger S (2015). Immunologische Effekte verschiedener Mistelextrakte in Wechselwirkung mit humanen Tumorzellüberständen – ein Modell mit Dendritischen Zellen, Universität Freiburg.

Roter DL, KJ Yost, T O'Byrne, M Branda, A Leppin, B Kimball, C Fernandez, A Jatoi, A Kumbamu, V Montori, B Koenig, G Geller, S Larson and J Tilburt: Communication predictors and consequences of Complementary and Alternative Medicine (CAM) discussions in oncology visits. Patient Educ Couns. 2016; 99: 1519-1525 http://www.ncbi.nlm.nih.gov/pubmed/27296081.

Saha C, M Das, E Stephen-Victor, A Friboulet, J Bayry and SV Kaveri: Differential Effects of Viscum album Preparations on the Maturation and Activation of Human Dendritic Cells and CD4(+) T Cell Responses. Molecules. 2016; 21 http://www.ncbi.nlm.nih.gov/pubmed/27428940.

Saller R, J Reichling and J Melzer (2004). Misteltherapie - Erwünschte und unerwünschte Wirkungen in der wissenschaftlichen Diskussion, Teil 1. Praxismagazin. 12: 6-15.

Saller R, J Reichling and J Melzer (2005). Misteltherapie - Erwünschte und unerwünschte Wirkungen in der wissenschaftlichen Diskussion, Teil 2. Praxismagazin. 2: 6-17.

Sander F (2008). Wirkung des Mistellektin-l auf das Wachstums- und Metastasierungsverhalten der humanen Melanomzelllinie MV3 in vivo in einem Xenograftmodell mit scid- und pfp/rag2-Mäusen. Dissertation, University Hamburg.

Schad F, J Axtner, A Happe, T Breitkreuz, C Paxino, J Gutsch, B Matthes, M Debus, M Kröz, G Spahn, H Riess, HB von Laue and H Matthes: Network Oncology (NO)--a clinical cancer register for health services research and the evaluation of integrative therapeutic interventions in anthroposophic medicine. Forsch Komplementmed. 2013; 20: 353-360 http://www.ncbi.nlm.nih.gov/pubmed/24200825.

Schad F, J Axtner, M Kröz, H Matthes and ML Steele: Safety of Combined Treatment With Monoclonal Antibodies and Viscum album L Preparations. Integr Cancer Ther. 2018; 17: 41-51.

Schad F, A Thronicke, A Merkle, H Matthes and ML Steele: Immune-related and adverse drug reactions to low versus high initial doses of Viscum album L. in cancer patients. Phytomedicine. 2017; 36: 54-58 http://www.ncbi.nlm.nih.gov/pubmed/29157828.

Schad F, A Thronicke, A Merkle, M Steele, M Kröz, C Herbstreit and H Matthes: Implementation of an integrative oncological concept in daily care of a German certified Breast Cancer Centre. Complement Med Res. 2018; 25: 85-91 https://www.ncbi.nlm.nih.gov/pubmed/29510405.

Schad F, A Thronicke, ML Steele, A Merkle, B Matthes, C Grah and H Matthes: Overall survival of stage IV non-small cell lung cancer patients treated with Viscum album L. in addition to chemotherapy, a real-world observational multicenter analysis. PLOS One. 2018; 13: e0203058 http://www.ncbi.nlm.nih.gov/pubmed/30148853.

Schink M and M Borowsky (2001). Zytotoxische Effekte von Mistellektinen und einem Mistelpräparat auf menschliche natürliche Killerzellen in vitro. Die Mistel in der Tumortherapie. R. Scheer, R. Bauer, H. Becker, A. P. Berg and V. Fintelmann. Essen, KCV Verlag: 163-176.

Schink M and O Dehus: Effects of mistletoe products on pharmacokinetic drug turnover by inhibition and induction of cytochrome P450 activities. BMC Complement Altern Med. 2017; 17: 521 www.ncbi.nlm.nih.gov/pubmed/29202738.
Schink M, W Tröger, A Dabidian, A Goyert, H Scheuerecker, J Meyer, IU Fischer and F Glaser: Mistletoe extract reduces the surgical suppression of natural killer cell activity in cancer patients. a randomized phase III trial. Forsch Komplementmed. 2007; 14: 9-17 http://www.ncbi.nlm.nih.gov/pubmed/17341882.

Schink M, W Tröger, A Goyert, H Scheuerecker, J Meyer, I Fischer and F Glaser (2009). Einfluss perioperativer Mistelextrakt-Infusionen auf eine operations- und narkosebedingte Immunsuppression bei Patienten mit kolorektalem Karzinom. Die Mistel in der Tumortherapie 2. R. Scheer, S. Alban, H. Becker et al. Essen, KVC Verlag: 441-454.

Schink M, W Tröger, A Goyert, H Scheuerecker, HK Selbmann and F Glaser: [Correlation of NK cell activity against autologous tumour cells and K562 cells with the clinical outcome during therapy with mistletoe extracts]. Forsch Komplementmed. 2006; 13: 147-155 http://www.ncbi.nlm.nih.gov/pubmed/16868360.

Seifert G, G Henze, G Calaminus, C vom Hoff-Heise, D Schlodder, S Rieger, J Felenda, C Beckmann, R Hufnagl, C Semaca and A Längler: Evaluation of an anthroposophic supportive treatment intervention (ASTI) in children with malignant diseases during intensive chemotherapy. Abstract. Phytomedicine. 2015; 22: S.18 http://doi.org/10.1016/j.phymed.2015.05.034.

Siegle I, P Fritz, M McClellan, S Gutzeit and TE Murdter: Combined cytotoxic action of Viscum album agglutinin-1 and anticancer agents against human A549 lung cancer cells. Anticancer Res. 2001; 21: 2687-2691 http://www.ncbi.nlm.nih.gov/pubmed/11724340.

Spahn G, V Schindler, C Heyder, H Rieß, A Gerhards, H von Laue, M Woernle, M Nabrotzki, G Leneweit, A Happe and F Schad (2013). An integrative approach of pancreatic carcinoma treatment using Viscum therapy - Results from the clinical register at the Clinic Öschelbronn 2007-2010., KVC Verlag  - Karl und Veronica Carstens-Stiftung, Essen.

Steele ML, J Axtner, A Happe, M Kröz, H Matthes and F Schad: Adverse Drug Reactions and Expected Effects to Therapy with Subcutaneous Mistletoe Extracts (Viscum album L.) in Cancer Patients. Evid Based Complement Alternat Med. 2014; 2014: 724258 http://www.ncbi.nlm.nih.gov/pubmed/24672577.

Steele ML, J Axtner, A Happe, M Kröz, H Matthes and F Schad: Safety of Intravenous Application of Mistletoe (Viscum album L.) Preparations in Oncology: An Observational Study. Evid Based Complement Alternat Med. 2014; 2014: 236310 http://www.ncbi.nlm.nih.gov/pubmed/24955100.

Steele ML, J Axtner, A Happe, M Kröz, H Matthes and F Schad: Use and Safety of Intratumoral Application of European Mistletoe (Viscum album L) Preparations in Oncology. Integrative Cancer Therapies. 2015; 14: 140-148.

Stein GM and PA Berg: Mistletoe extract-induced effects on immunocompetent cells: in vitro studies. Anticancer Drugs. 1997; 8 Suppl 1: S39-42 http://www.ncbi.nlm.nih.gov/pubmed/9179366.

Stein GM and PA Berg (2000). Adverse effects during therapy with mistletoe extracts. Mistletoe The Genus Viscum. A. Büssing, Amsterdam, Hardwood Academic Publishers: 195-208.

Stein GM, U Edlund, G Schaller, U Pflüller, A Büssing and M Schietzel (2001). Polysaccharide und Viscotoxine – Immunologische Wirkungen und Interaktionen. Die Mistel in der Tumortherapie. R. Scheer, R. Bauer, H. Becker, A. P. Berg and V. Fintelmann. Essen, KVC Verlag: 145-161.

Stein GM, A Stettin, J Schultze and PA Berg: Induction of anti-mistletoe lectin antibodies in relation to different mistletoe-extracts. Anticancer Drugs. 1997; 8 Suppl 1: S57-59 http://www.ncbi.nlm.nih.gov/pubmed/9179370.

Steinborn C, AM Klemd, AS Sanchez-Campillo, S Rieger, M Scheffen, B Sauer, M Garcia-Kaufer, K Urech, M Follo, A Ucker, GS Kienle, R Huber and C Grundemann: Viscum album neutralizes tumor-induced immunosuppression in a human in vitro cell model. PLOS One. 2017; 12: e0181553 http://www.ncbi.nlm.nih.gov/pubmed/28719632.

Stettin A, JL Schultze, E Stechemesser and PA Berg: Anti-mistletoe lectin antibodies are produced in patients during therapy with an aqueous mistletoe extract derived from Viscum album L. and neutralize lectin-induced cytotoxicity in vitro. Klin Wochenschr. 1990; 68: 896-900 http://www.ncbi.nlm.nih.gov/pubmed/2124308.

Tabiasco J, F Pont, JJ Fournie and A Vercellone: Mistletoe viscotoxins increase natural killer cell-mediated cytotoxicity. Eur J Biochem. 2002; 269: 2591-2600 http://www.ncbi.nlm.nih.gov/pubmed/12027898.

Tasaki K, G Maskarinec, DM Shumay, Y Tatsumura and H Kakai: Communication between physicians and cancer patients about complementary and alternative medicine: exploring patients' perspectives. Psychooncology. 2002; 11: 212-220 http://www.ncbi.nlm.nih.gov/pubmed/12112481.

Templeton AJ, B Thurlimann, M Baumann, M Mark, S Stoll, M Schwizer, D Dietrich and T Ruhstaller: Cross-sectional study of self-reported physical activity, eating habits and use of complementary medicine in breast cancer survivors. BMC Cancer. 2013; 13: 153 http://www.ncbi.nlm.nih.gov/pubmed/23530694.

Thronicke A, M Kröz, M Steele, H Matthes, C Herbstreit and F Schad: Health related quality of life of breast cancer patients receiving non-pharmacological interventions within a multimodal integrative concept of a certified breast cancer centre. Abstract. BMC Complement Altern Med. 2017; 17: 317 https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/s12906-017-1783-3.

Thronicke A, A Merkle and F Schad: Das Netzwerk Onkologie im Jahr 2017 – Evaluierung integrativer Behandlungskonzepte der Onkologie im Versorgungsalltag. Jahresbericht des Vereins für Krebsforschung. 2017; http://www.vfk.ch/informationen/jahresbericht/.

Thronicke A, S Oei, C Grah, B Matthes and F Schad: Nivolumab-induced toxicity profile in patients with advanced or metastasized lung cancer treated with Viscum album L. extracts. Abstract. Presented at: 33. Deutscher Krebskongress 2018 (DKK2018); 2018; Berlin. 2018.

Thronicke A, SL Oei, A Merkle, M H and F Schad: Clinical Safety of Combined Targeted and Viscum album L. Therapy in Oncological Patients. Medicines (Basel). 2018; 5: 100. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164814/

Thronicke A, SL Oei, A Merkle, C Herbstreit, HP Lemmens, C Grah, M Kröz, H Matthes and F Schad: Integrative cancer care in a certified Cancer Centre of a German Anthroposophic hospital. Complement Ther Med. 2018; 40: 151-157 http://www.ncbi.nlm.nih.gov/pubmed/30219441.

Thronicke A, SL Oei, A Merkle, H Matthes and F Schad: Clinical Safety of Combined Targeted and Viscum album L. Therapy in Oncological Patients. Medicines (Basel). 2018; 5 http://www.ncbi.nlm.nih.gov/pubmed/30200590.

Thronicke A, ML Steele, C Grah, B Matthes and F Schad: Clinical safety of combined therapy of immune checkpoint inhibitors and Viscum album L. therapy in patients with advanced or metastatic cancer. BMC Complement Altern Med. 2017; 17: 534 http://www.ncbi.nlm.nih.gov/pubmed/29237435.

Tröger W, D Galun, M Reif, A Schumann, N Stankovic and M Milicevic: Viscum album [L.] extract therapy in patients with locally advanced or metastatic pancreatic cancer. A randomised clinical trial on overall survival. European Journal of Cancer. 2013; 49: 3788-3797 https://www.ejcancer.com/article/S0959-8049(13)00550-9/pdf.

Tröger W, D Galun, M Reif, A Schumann, N Stankovic and M Milicevic: Quality of life of patients with advanced pancreatic cancer during treatment with mistletoe: a randomized controlled trial. Dtsch Arztebl Int. 2014; 111: 493-502, 433 p following 502 http://www.ncbi.nlm.nih.gov/pubmed/25142075.

Tröger W, S Jezdic, Z Zdrale, N Tisma, HJ Hamre and M Matijasevic: Quality of life and neutropenia in patients with early stage breast cancer: a randomized pilot study comparing additional treatment with mistletoe extract to chemotherapy alone. Breast Cancer. 2009; 16: 35-45 https://www.ncbi.nlm.nih.gov/pubmed/21556248.

Tröger W, Z Zdrale and N Stankovic: Fünf-Jahres-Nachbeobachtung von Patientinnen mit Brustkrebs nach einer randomisierten Studie mit Viscum album (L.) Extrakt. Deutsche Zeitschrift für Onkologie. 2016; 48: 105-110 https://www.thieme-connect.com/products/ejournals/pdf/10.1055/s-0042-113505.pdf.

Tröger W, Z Zdrale, N Stankovic and M Matijasevic: Five-year follow-up of patients with early stage breast cancer after a randomized study comparing additional treatment with viscum album (L.) extract to chemotherapy alone. Breast Cancer (Auckl). 2012; 6: 173-180 http://www.ncbi.nlm.nih.gov/pubmed/23150723.

Tröger W, Z Zdrale, N Tisma and M Matijasevic: Additional Therapy with a Mistletoe Product during Adjuvant Chemotherapy of Breast Cancer Patients Improves Quality of Life: An Open Randomized Clinical Pilot Trial. Evidence-Based Complementary and Alternative Medicine. 2014; 2014: 01. Sep http://downloads.hindawi.com/journals/ecam/2014/430518.pdf.

Urech K and S Baumgartner (2015). Chemical constituents of Viscum album L.: Implications for the pharmaceutical preparation of mistletoe. Mistletoe - From mythology to evidence-based medicine. Translational Research in Biomedicine. Basel, Karger Verlag. 4: 11-23.

Urech K, A Büssing, G Thalmann, H Schäfermeyer and P Heusser: Antiproliferative effects of mistletoe (Viscum album L) extract in urinary bladder carcinoma cell lines. Anti-Cancer Research. 2006; 26: 3049-3056.

Urech K, C Jäggy and G Schaller (2009). Räumliche und zeitliche Dynamik der Viscotoxin- und Mistellektingehalte in der Mistel (Viscum album L.). Die Mistel in der Tumortherapie 2. R. Scheer, S. Alban, H. Becker et al. Essen, KVC Verlag: 67-77.

Urech K, G Schaller and C Jaggy: Viscotoxins, mistletoe lectins and their isoforms in mistletoe (Viscum album L.) extracts Iscador. Arzneimittelforschung. 2006; 56: 428-434 http://www.ncbi.nlm.nih.gov/pubmed/16927522.

Urech K, JM Scher, K Hostanska and H Becker: Apoptosis inducing activity of viscin, a lipophilic extract from Viscum album L. J Pharm Pharmacol. 2005; 57: 101-109 http://www.ncbi.nlm.nih.gov/pubmed/15638998.

van Huyen JPD, S Delignat, J Bayry, MD Kazatchkine, lP Bruneva, A Nicoletti and SV Kaveri: Interleukin-12 is associated with the in vivo anti-tumor effect of mistletoe extracts in B16 mouse melanoma. Cancer Lett. 2006; 243: 32-37.

von Hagens C, A Loewe-Mesch, JJ Kuehn, U Abel and I Gerhard (2005). Prospektive kontrollierte nicht randomisierte Machbarkeits-Studie zu einer postoperativen simultanen Mistel-/Chemotherapie bei Patientinnen mit Mammakarzinom - Ergebnisse zu Rekrutierbarkeit, Immunparametern, Lebensqualität und Verträglichkeit. Fortschritte in der Misteltherapie. Aktueller Stand der Forschung und klinischen Anwendung. R. Scheer, R. Bauer, H. Becker et al., Essen, KVC Verlag 567-578.

von Schoen-Angerer T, J Wilkens, GS Kienle, H Kiene and J Vagedes: High-Dose Viscum album Extract Treatment in the Prevention of Recurrent Bladder Cancer: A Retrospective Case Series. Perm J. 2015; 19: 76-83 http://www.ncbi.nlm.nih.gov/pubmed/26517439.

Weis J, HH Bartsch, F Hennies, M Rietschel, M Heim, G Adam, U Gärtner and A Ammon: Complementary medicine in cancer patients: Demand, patients' attitudes and psychological beliefs. Onkologie. 1998; 21: 144-149.

Weissenstein U, M Kunz, M Oufir, JT Wang, M Hamburger, K Urech, U Regueiro and S Baumgartner: Absence of herb-drug interactions of mistletoe with the tamoxifen metabolite (E/Z)-endoxifen and cytochrome P450 3A4/5 and 2D6 in vitro. BMC Complement Altern Med. 2019; 19: 23 http://www.ncbi.nlm.nih.gov/pubmed/30658716.

Weissenstein U, M Kunz, K Urech and S Baumgartner: Interaction of standardized mistletoe (Viscum album) extracts with chemotherapeutic drugs regarding cytostatic and cytotoxic effects in vitro. BMC Complementary and Alternative Medicine. 2014; 14: 01. Sep https://bmccomplementalternmed.biomedcentral.com/track/pdf/10.1186/1472-6882-14-6.

Weissenstein U, M Kunz, K Urech and S Baumgartner: Interaction of standardized mistletoe (Viscum album) extracts with chemotherapeutic drugs regarding cytostatic and cytotoxic effects in vitro. BMC Complement Altern Med. 2014; 14: 6 http://www.ncbi.nlm.nih.gov/pubmed/24397864.

Weissenstein U, M Kunz, K Urech, U Regueiro and S Baumgartner: Interaction of a standardized mistletoe (Viscum album) preparation with antitumor effects of Trastuzumab in vitro. BMC Complement Altern Med. 2016; 16: 271 http://www.ncbi.nlm.nih.gov/pubmed/27491866.

Werthmann PG, D Helling, P Heusser and GS Kienle: Tumour response following high-dose intratumoural application of Viscum album on a patient with adenoid cystic carcinoma. BMJ Case Rep. 2014; 2014 http://www.ncbi.nlm.nih.gov/pubmed/25082867.

Werthmann PG, A Hintze and GS Kienle: Complete remission and long-term survival of a patient with melanoma metastases treated with high-dose fever-inducing Viscum album extract: A case report. Medicine (Baltimore). 2017; 96: e8731 http://www.ncbi.nlm.nih.gov/pubmed/29145317.

Werthmann PG, R Huber and GS Kienle: Durable clinical remission of a skull metastasis under intralesional Viscum album extract therapy: Case report. Head Neck. 2018; 40: E77-E81 http://www.ncbi.nlm.nih.gov/pubmed/29885069.

Werthmann PG, P Inter, T Welsch, AK Sturm, R Grutzmann, M Debus, MG Sterner and GS Kienle: Long-term tumor-free survival in a metastatic pancreatic carcinoma patient with FOLFIRINOX/Mitomycin, high-dose, fever inducing Viscum album extracts and subsequent R0 resection: A case report. Medicine (Baltimore). 2018; 97: e13243 http://www.ncbi.nlm.nih.gov/pubmed/30544385.

Werthmann PG, R Kempenich and GS Kienle: Long-Term Tumor-Free Survival in a Patient with Stage IV Epithelial Ovarian Cancer Undergoing High-Dose Chemotherapy and Viscum album Extract Treatment: A Case Report. Perm J. 2018; 23: 18-025 http://www.ncbi.nlm.nih.gov/pubmed/30589407.

Werthmann PG, L Kindermann and GS Kienle: A 21-year course of Merkel cell carcinoma with adjuvant Viscum album extract treatment: A case report. Complement Ther Med. 2018; 38: 58-60 http://www.ncbi.nlm.nih.gov/pubmed/29857880.

Werthmann PG, G Strater, H Friesland and GS Kienle: Durable response of cutaneous squamous cell carcinoma following high-dose peri-lesional injections of Viscum album extracts--a case report. Phytomedicine. 2013; 20: 324-327 http://www.ncbi.nlm.nih.gov/pubmed/23394841.

Winterfeld K and AB Bijnen: Viscotoxin, ein neuer Inhaltsstoff der Mistel (Viscum album L.). Liebigs Ann Chem. 1948; 561: 107-115.

Witt CM, LG Balneaves, MJ Cardoso, L Cohen, H Greenlee, P Johnstone, O Kucuk, J Mailman and JJ Mao: A Comprehensive Definition for Integrative Oncology. J Natl Cancer Inst Monogr. 2017; 2017 http://www.ncbi.nlm.nih.gov/pubmed/29140493.

Witt CM and MJ Cardoso: Complementary and integrative medicine for breast cancer patients - Evidence based practical recommendations. The Breast. 2016; 28: 37-44 

Wode K, T Schneider, I Lundberg and GS Kienle: Mistletoe treatment in cancer-related fatigue: a case report. Cases J. 2009; 2: 77 http://www.ncbi.nlm.nih.gov/pubmed/19161607.

Wong CK, J Zhang, WK Ip and CW Lam: Intracellular signal transduction in eosinophils and its clinical significance. Immunopharmacol Immunotoxicol. 2002; 24: 165-186 http://www.ncbi.nlm.nih.gov/pubmed/12066845.

Zaenker K: A Specific Mistletoe Preparation (Iscador-Qu®) in Colorectal Cancer (CRC) Patients: More than Just Supportive Care? Journal of Cancer Science & Therapy. 2012.

Ziegler R and R Grossarth-Maticek: Individual Patient Data Meta-analysis of Survival and Psychosomatic Self-regulation from Published Prospective Controlled Cohort Studies for Long-term Therapy of Breast Cancer Patients with a Mistletoe Preparation (Iscador). Evid Based Complement Alternat Med. 2010; 7: 157-166 http://www.ncbi.nlm.nih.gov/pubmed/18955332  

 

Letzte Aktualisierung: 4. September 2019/AB

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